Do increased serum IL-12 and IL-23 levels affect cognitive function in patients with multiple sclerosis? A preliminary study

Aim of the study: To compare serum levels IL-12 and IL-23 between healthy volunteers patients with multiple sclerosis regard to their cognitive function. Materials methods: A total 21 individuals were enrolled into study. The age- sex-matched. Each participant was evaluated using Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI). enzyme-linked immunosorbent assay performed assess IL-23. Results: concentration 1.61 ± 4.61 pg/mL in group 1.78 3.54 control group, p = 0.5009. 19.04 75.50 study 5.50 14.4 0.5170. significant difference found groups MoCA test (28 vs. 24 points, respectively, < 0.0001). There no PSQI groups. No correlations IL-12/IL-23 psychological evaluations. Conclusions clinical implications: results obtained indicate that may not play a role development impairment. assessment impairment have screening value preventing deterioration.